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Oxycodone is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient.It may improve quality of life in certain types of pain.It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief.
Oxycodone is available as a controlled-release tablet, intended to be taken every 12 hours. A July 1995 study independent of Purdue Pharma, the drug’s originator, found the controlled-release formulation had a variable duration of action ranging from 10 to 12 hours. 2006 review found that controlled-release oxycodone is comparable to immediate-release oxycodone, morphine, and hydromorphone in management of moderate to severe cancer pain, with fewer side effects than morphine. The author concluded that the controlled-release form is a valid alternative to morphine and a first-line treatment for cancer pain. In 2014, the European Association for Palliative Care recommended oxycodone by mouth as a second-line alternative to morphine by mouth for cancer pain.